Characterization of bacterial RNA and DNA signalling pathways that induce cellular dysfunction
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Characterization of bacterial RNA and DNA signalling pathways that induce cellular dysfunction

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Published by Laurentian University in Sudbury, Ont .
Written in English

Book details:

Edition Notes

Statementby Viktoria Kekkonen.
The Physical Object
Paginationvi, 45 l. :
Number of Pages45
ID Numbers
Open LibraryOL22179255M

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Bacterial DNA differs from eukaryotic DNA in its frequency of the dinucleotides CG and its lack of methylation. These structural differences appear to be sensed by cells of the innate immune system such as antigen-presenting cells. As a consequence bacterial DNA serves as an alternate ligand to signal danger of by:   On page of this issue, Graves et al. 1 describe a hitherto unknown link between an enzyme that is critical for nucleotide synthesis and a growth-factor-induced signal-transduction pathway. The biological outcome of the Ca2+ oscillations induced by ClyA+OMV is currently unknown. System biology can provide a new facilitating tool to investigating these complex molecular pathways involved in toxin-induced Ca2+ signaling. We present the first theoretical study describing Ca2+ oscillations involving a pore-forming toxin. -RNA transcript produced from DNA in the centromeric region of the chromosome is copied into double-stranded RNA by a yeast enzyme and then processed into siRNAs. These siRNAs associate with a complex of proteins and act as a homing device, targeting the complex back to the centromeric sequences of DNA.